Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.

中文翻译：

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爆炸纳米金刚石作为有前途的药物载体

综述了在生物医学应用中使用爆炸纳米金刚石 (DND) 的信息。介绍了文献数据和我们自己在制备具有生物活性化合物的 DND 缀合物和纳米金刚石的体内分布方面的结果。确定了设计 DND 系统以提供生物活性化合物和药物的主要发展方向。DND 对生物医学应用很有吸引力，因为它们的属性集包括生物相容性、使颗粒表面功能化的能力、药物和生物分子的强和特异性吸附/结合、大比表面积和稳定的荧光。