Rheological parameters and morphologies of original and generic creams and ointments for external application containing the active ingredients methylprednisolone acetonate or a combination of betamethasone dipropionate, gentamicin sulfate, and clotrimazole were compared. Flow rheometry at various temperatures was used to measure viscosity curves, thixotropic rheograms, and frequency dependences of the elastic and viscosity moduli of both medicines. The morphologies of the medicines were also evaluated by optical microscopy. The differences in the rheological and morphological properties were most significant between Triderm, Akriderm GC, and Canison Plus creams and between Triderm and Akriderm GC ointments. Advantan and Comfoderm ointments belonged to different dispersion classes so that their morphologies and rheological parameters differed significantly.

中文翻译：

---

外用药膏或软膏的流变学和形态学比较

比较了含有活性成分丙酮酸甲基强的松龙或倍他米松二丙酸酯、硫酸庆大霉素和克霉唑的组合的原始和仿制药外用乳膏和软膏的流变学参数和形态。使用不同温度下的流动流变法来测量两种药物的粘度曲线、触变流变图以及弹性和粘度模量的频率依赖性。还通过光学显微镜评估了药物的形态。Triderm、Akrider GC 和 Canison Plus 乳膏之间以及 Triderm 和 Akrider GC 软膏之间的流变学和形态学特性差异最为显着。