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Antimicrobial Activity of Lyophilized Aqueous Extract from Caragana Jubata (Pall.) Poir.
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2020-06-01 , DOI: 10.1007/s11094-020-02193-z
P. A. Kakorin , T. V. Fateeva , O. I. Tereshkina , I. B. Perova , G. V. Ramenskaya , S. S. Sologova , K. I. Eller

The flavonoid profile of the lyophilized aqueous extract of Caragana jubata shoots was established based on previous studies. The antimicrobial activity of the lyophilizate was studied in vitro using a screening method for determining the antimicrobial activity of herbal preparations because the flavonoids were potential microorganism inhibitors according to the literature. The bacteriostatic and fungistatic activity was studied in vitro using double serial dilutions of the preparations in liquid growth media. The results revealed moderate antimicrobial activity of the lyophilized aqueous extract of C. jubata against all tested strains of pathogenic Gram-positive and Gram-negative bacteria ( S. aureus , E. coli , P. vulgaris , P. aeruginosa ) and yeast-like and mycelial fungi ( C. albicans , M. canis ). The results allowed the lyophilized aqueous extract to be recommended for treating skin and mucous membrane diseases associated with bacterial inflammatory processes.

中文翻译:

来自 Caragana Jubata (Pall.) Poir 的冻干水提取物的抗菌活性。

锦鸡儿嫩枝冻干水提取物的类黄酮谱是根据先前的研究确定的。由于根据文献,类黄酮是潜在的微生物抑制剂,因此使用确定草药制剂的抗微生物活性的筛选方法在体外研究了冻干物的抗微生物活性。使用液体生长培养基中制剂的双重连续稀释在体外研究抑菌和抑真菌活性。结果表明,红枣冻干水提取物对所有测试的致病性革兰氏阳性菌和革兰氏阴性菌(金黄色葡萄球菌、大肠杆菌、普通假单胞菌、铜绿假单胞菌)和酵母样菌具有中等抗菌活性。和菌丝体真菌(C. albicans , M. canis )。
更新日期:2020-06-01
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