Abstract

A unique one-pot, simultaneous nitrodebromination and methyl bromonitration occurred upon treatment of 5-bromo-2,4-di-tert-amino-6-methylpyrimidine derivatives with a cold mixture of concentrated H₂SO₄–HNO₃ in moderate yields. It is actually a facile and rapid transformation that has been reported neither on pyrimidines nor simultaneously on other organic compounds.

Graphic abstract

中文翻译：

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一锅硝基溴化和5-溴6-甲基嘧啶的甲基双功能化：独特的同时转化

摘要

用浓H ₂ SO ₄ -HNO ₃的冷混合物处理5-溴-2,4-二叔-氨基-6-甲基嘧啶衍生物后，会发生独特的一锅同时硝化溴化和甲基溴化反应，产率中等。实际上，这是一种既简便又迅速的转化，既没有关于嘧啶的报道，也没有关于其他有机化合物的报道。

图形摘要