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Studies towards a new C-alkylation method at 3-position of indoles
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2020-07-07 , DOI: 10.1007/s00706-020-02645-y Gopi Reddy Raveendra Reddy , Aluru Rammohan , Thummaluru Veera Reddy , Luo Yunfei , Grigory V. Zyryanov
中文翻译:
对吲哚3位C-烷基化新方法的研究
更新日期:2020-07-07
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2020-07-07 , DOI: 10.1007/s00706-020-02645-y Gopi Reddy Raveendra Reddy , Aluru Rammohan , Thummaluru Veera Reddy , Luo Yunfei , Grigory V. Zyryanov
Abstract
We report a new facile synthesis procedure for the C-alkylation reaction of indole and indole derivative at 3-position with cyclic enol ethers in the presence of 2.5 mol% of I2 under mild conditions. The optimum composition of the reaction mixture and catalyst were determined for maximum yield of C-alkylated indole derivative with molar ratio of indole derivative: cyclic enol ether was fixed at 1.0 equivalence: 1.5 equivalence with the presence of 2.5 mol% of I2 in acetonitrile solvent and room temperature conditions. The results showed that under optimum conditions indole derivatives can be obtained good to excellent yields (80–92%) by the C-alkylation of indoles with cyclic enol ethers.Graphic abstract
中文翻译:
对吲哚3位C-烷基化新方法的研究