Abstract

The synthesis of 4-substituted 2-(2-arylhydrazinyl)thiazol-3-ium bromides and 4-aryl-2-(substituted amino)-3-(phenylamino)thiazol-3-ium bromide derivatives in high yields from the interaction of mono- and di-substituted thiosemicarbazides with phenacyl bromide derivatives is reported. The synthesized products have been elucidated using various spectroscopic tools such as IR, NMR, and mass spectrometry. Also the structure of three of the obtained compounds have been confirmed using X-ray crystallographic analyses, which showed that compounds 2-[2-(2,4-dinitrophenyl)hydrazinyl]-4-phenylthiazol-3-ium bromide and 4-phenyl-2,3-bis(phenylamino)thiazol-3-ium bromide crystals have a monoclinic shape and belonged to space group P2₁/c, whereas the crystals of 4-phenyl-2-(2-tosylhydrazinyl)thiazol-3-ium bromide show an orthorhombic shape with the space group Pbca

Graphic abstract

中文翻译：

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2,4-二取代噻唑和2,3,4-三取代噻唑作为噻唑鎓溴化物盐的合成与结构确认

摘要

由-的相互作用高产率合成4-取代的2-（2-芳肼基）噻唑-3-溴化物和4-芳-2-取代的氨基-3-苯基氨基噻唑-3-溴化物衍生物。据报道具有苯甲酰溴衍生物的单取代和二取代的硫代氨基脲。已使用各种光谱工具（例如IR，NMR和质谱法）阐明了合成产物。还使用X射线晶体学分析证实了所获得的三种化合物的结构，这表明化合物2- [2-（2,4-二硝基苯基）肼基] -4-苯基噻唑-3-溴化铵和4-苯基-2,3-双（苯基氨基）噻唑-3-溴化铵晶体为单斜晶体，属于空间群P2 ₁ / c，而4-苯基-2-（2-甲苯磺酰肼基）噻唑-3-溴化铵的晶体呈正交晶形，空间群为Pbca

图形摘要