Abstract

The one-pot three-component synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile derivatives by the reaction between various aldehydes with 2-aminobenzimidazole and malononitrile with an excellent output and in low-response period was studied in the presence of Ag–TiO₂ nanocomposite as an efficient and recyclable catalyst under solvent-free conditions at 60 °C. The results indicated that the isolation of the desired products could be attained via simple filtration, and the Ag–TiO₂ nanocomposite could be reusable and reused continuously.

Graphic abstract

中文翻译：

---

Ag-TiO 2纳米复合材料是无溶剂条件下合成咪唑-嘧啶衍生物的有效和可循环使用的催化剂

摘要

通过各种醛与2-的反应，一锅三组分合成2-氨基-4-取代的1,4-二氢苯并[4,5]咪唑并[1,2 - a ]嘧啶-3-腈在无溶剂条件下于60°C的条件下，以Ag-TiO ₂纳米复合材料作为有效和可回收的催化剂，研究了氨基苯并咪唑和丙二腈具有优异的产量和低响应时间。结果表明，所需产物的分离可通过简单过滤实现，并且Ag-TiO ₂纳米复合材料可重复使用并连续重复使用。

图形摘要