Abstract

In this work, the sonosynthesis of a fluorescent nanocarrier based on iron oxide nanoparticles (mainly magnetite) conjugated with cisplatin, ethylene glycol (EG) and folic acid (FA) is presented. A spectroscopic study on the formation of a complex Fe(II)–FA was performed with the aim of evaluating how the adsorption of FA onto the magnetite takes place. The magnetite ferrofluids were characterized by Raman microspectroscopy, Transmission electron microscopy (TEM), UV–Vis spectroscopy (absorbance and fluorescence), X-ray fluorescence (TXRF) and X-ray diffraction (XRD). The structural analysis shows that Pt is part of the crystal structure of the system together with magnetite. The study also demonstrates that the cisplatin–folate interaction results in a less stable ferrofluid than that obtained in the absence of Pt. However, unlike the latter, the former shows fluorescence.

Graphic abstract

Magnetic and fluorescent Trojan Horse containing platinum

中文翻译：

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基于磁性纳米粒子的荧光特洛伊木马的超声合成与表征

摘要

在这项工作中，提出了一种基于氧化铁纳米粒子（主要是磁铁矿）与顺铂，乙二醇（EG）和叶酸（FA）结合的荧光纳米载体的超声合成。对形成复杂的Fe（II）-FA进行了光谱研究，目的是评估FA在磁铁矿上的吸附方式。磁铁矿铁磁流体的特征在于拉曼光谱，透射电子显微镜（TEM），紫外可见光谱（吸收和荧光），X射线荧光（TXRF）和X射线衍射（XRD）。结构分析表明，Pt与磁铁矿一起是系统晶体结构的一部分。该研究还表明，与不存在Pt的情况相比，顺铂-叶酸的相互作用导致铁磁流体的稳定性差。但是，与后者不同

图形摘要

含铂的磁性和荧光特洛伊木马