Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence of genistein on the maternal bone and placenta mineral composition. Pregnant rats were grouped into control, 2 mg/kg and 4 mg/kg genistein groups, dosed accordingly till sacrificed at different gestation days (GD). Body and placenta weights, right femur bone and placenta mineral composition were analysed. A significant decrease in body weight and percentage relative right femur bone weight at GD-20 was recorded in the 2-mg group with the reverse occurring in the 4-mg genistein group. The right femur bone Ca²⁺ and Zn²⁺ was reduced towards GD-20 in both 2-mg and 4-mg genistein groups. Genistein had no influence on placenta selenium and cadmium level, but significantly decreased zinc and lead level concentration as the gestation progressed towards GD-20. Copper level was increased at GD-16 at the doses used. Genistein modulated maternal bone mineral composition and placenta capability in retaining some heavy metals at various stages of pregnancy.

怀孕是一个关键时期，为母亲和发育中的胎儿提供必需矿物质的需求增加，并且当这些矿物质的需求和供应之间没有平衡时，有改变母体骨矿物质密度的趋势。本研究评估了染料木素对母体骨骼和胎盘矿物质成分的影响。将孕鼠分为对照组、2 mg/kg染料木黄酮组和4 mg/kg染料木黄酮组，相应给药至不同孕周(GD)处死。分析了体重和胎盘重量、右股骨和胎盘矿物质成分。在 GD-20 时体重和相对右股骨重量百分比在 2-mg 组中显着下降，而在 4-mg 染料木黄酮组中出现相反的情况。右股骨 Ca ²⁺和 Zn^{在 2-mg 和 4-mg 染料木黄酮组中，2 +}均降低至 GD-20。金雀异黄素对胎盘硒和镉水平没有影响，但随着妊娠进展到 GD-20，锌和铅水平浓度显着降低。在所用剂量下，铜水平在 GD-16 时增加。金雀异黄素调节母体骨矿物质成分和胎盘在妊娠不同阶段保留一些重金属的能力。