The vast majority of techniques to study the physiology of the nervous system involve inserting probes into the brain for stimulation, recording, or sampling. Research is increasingly uncovering the fine microstructure of the brain, each of its regions with dedicated functions. Accurate knowledge of the placement of probes interrogating these regions is critical. We have developed a customizable concentric marking electrode (CME) consisting of an iron core within a 125 μ m-stainless steel (SS) sheath for co-localization of targeted regions in the brain. We used a dielectric layer stack of SiO 2 , Al 2 O 3 , SiO 2 to electrically encapsulate the iron core and minimize exposure area to avoid significant increases in inflammatory response triggered by the probes. The CME can record multi-neuronal extracellular firing patterns. Appropriate electrical polarity of the iron and SS components controls the deposition of iron microdeposits on bra...

中文翻译：

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同时记录和标记大脑微结构。

绝大多数研究神经系统生理学的技术都涉及将探针插入大脑以进行刺激、记录或采样。越来越多的研究揭示了大脑的精细微观结构，它的每个区域都有专门的功能。准确了解询问这些区域的探针的位置是至关重要的。我们开发了一种可定制的同心标记电极 (CME)，该电极由 125 μ m 不锈钢 (SS) 护套内的铁芯组成，用于大脑中目标区域的共定位。我们使用 SiO 2 、Al 2 O 3 、SiO 2 的电介质层堆叠来电封装铁芯并最小化暴露区域，以避免探针触发的炎症反应显着增加。CME 可以记录多神经元细胞外放电模式。