Analysis of structural and dynamic properties of water in suspensions of liposomes composed from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in three phase states (gel, rippled gel, liquid crystalline phase) by means of terahertz time-domain spectroscopy in 0.3-3.3 THz range was conducted in the current work. Fraction of free water molecules in DPPC liposome suspension was shown to decrease with temperature (compared to the analogous aqueous solution without liposomes), and intermolecular water binding was enhanced. The most crucial changes occur during gel-rippled gel phase transition (pretransition): at temperatures below pretransition point, liposomes alleviate water binding degree, while at temperatures above the transition point, they enhance water binding. This study has demonstrated the high information content of the terahertz time-domain spectroscopy method for exploring the hydration properties of phospholipids in water.

中文翻译：

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EXPRESS：从太赫兹时域光谱的角度看 DPPC 脂质体的水合壳

通过太赫兹时间分析由三相状态（凝胶、波纹凝胶、液晶相）的 1,2-二棕榈酰-sn-甘油-3-磷酸胆碱 (DPPC) 组成的脂质体悬浮液中水的结构和动力学特性-在当前的工作中进行了 0.3-3.3 THz 范围内的域光谱。DPPC 脂质体悬浮液中游离水分子的分数显示出随温度降低（与没有脂质体的类似水溶液相比），并且分子间水结合增强。最关键的变化发生在凝胶波纹凝胶相变（预转变）期间：在低于预转变点的温度下，脂质体降低了水结合度，而在高于转变点的温度下，它们增强了水结合。