The sensitivity of pigs to deoxynivalenol (DON) might be influenced by systemic inflammation (SI) which impacts liver. Besides following acute-phase proteins, our aim was to investigate both the hepatic fractional albumin (ALB) synthesis rate (FSR) and the ALB concentration as indicators of ALB metabolism in presence and absence of SI induced by LPS via pre- or post-hepatic venous route. Each infusion group was pre-conditioned either with a control diet (CON, 0.12 mg DON/kg diet) or with a DON-contaminated diet (DON, 4.59 mg DON/kg diet) for 4 wk. A depression of ALB FSR was observed 195 min after LPS challenge, independent of feeding group or LPS application route, which was not paralleled by a down-regulated ALB mRNA expression but by a reduced availability of free cysteine. The drop in ALB FSR only partly explained the plasma ALB concentrations which were more depressed in the DON-pre-exposed groups, suggesting that ALB levels are influenced by further mechanisms. The abundances of haptoglobin, C-reactive protein, serum amyloid A, pig major acute-phase protein, fibrinogen and LPS-binding protein mRNA were up-regulated upon LPS stimulation but not accompanied by increases in the plasma concentrations of these proteins, pointing at an imbalance between synthesis and consumption.

猪对脱氧雪腐镰刀菌烯醇 (DON) 的敏感性可能受到影响肝脏的全身炎症 (SI) 的影响。除了跟踪急性期蛋白外，我们的目标是研究肝脏部分白蛋白 (ALB) 合成率 (FSR) 和 ALB 浓度作为 ALB 代谢的指标，在​​存在和不存在由 LPS 通过肝前或肝后诱导的 SI 的情况下静脉途径。每个输注组都用对照饮食（CON，0.12 mg DON/kg 饮食）或 DON 污染饮食（DON，4.59 mg DON/kg 饮食）预处理 4 周。在 LPS 攻击后 195 分钟观察到 ALB FSR 的降低，这与喂养组或 LPS 应用途径无关，这与 ALB mRNA 表达下调无关，而是与游离半胱氨酸的可用性降低相平行。ALB FSR 的下降仅部分解释了在 DON 预暴露组中血浆 ALB 浓度更受抑制，这表明 ALB 水平受进一步机制的影响。结合珠蛋白、C 反应蛋白、血清淀粉样蛋白 A、猪主要急性期蛋白、纤维蛋白原和 LPS 结合蛋白 mRNA 的丰度在 LPS 刺激后上调，但不伴随这些蛋白质的血浆浓度增加，指出合成与消耗之间的不平衡。