EXPAREL® has been used successfully to prolong postoperative pain control when applied as a wound infiltrate. EXPAREL® has not yet been approved for use in regional anesthesia to prolong postoperative pain control. We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks via the popliteal fossa approach. Our results suggested that there is a large degree of variability in response to the medication. These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial.

中文翻译：

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EXPAREL®（长效脂质体布比卡因）用于Pop神经固定，用于踝关节骨折固定术后的疼痛控制。

当作为伤口浸润液使用时，EXPAREL®已成功用于延长术后疼痛的控制。EXPAREL®尚未被批准用于区域麻醉以延长术后疼痛控制。我们通过EXP窝方法使用EXPAREL®进行坐骨神经阻滞，对4例患者进行了临床病例系列研究。我们的结果表明，对药物的反应存在很大程度的差异。这些不一致的结果以及在我们两名患者中看到的双峰动力学可能产生止痛药的可能性表明，需要更多的更大样本量的研究来更好地表征这些现象，并确定在未来的临床试验中是否可以获得更一致的结果。