Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for development of better long-acting penicillin preparations to prevent RHD. We hypothesized that subcutaneous (SC) administration of benzathine penicillin G could delay penicillin absorption when compared with IM injections.

中文翻译：

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与肌内注射相比，皮下注射苄星青霉素G具有预防风湿性心脏病的良好药代动力学特性：一项针对健康成人志愿者的随机，交叉，人群药代动力学研究。

自1950年代以来，苄星青霉素G被用作每月一次的深度肌肉内（IM）注射剂，用于急性风湿热和风湿性心脏病（RHD）的二级预防。注射频率和疼痛是依从性的主要程序障碍，促使人们呼吁开发更好的长效青霉素制剂来预防RHD。我们假设与IM注射相比，皮下（SC）施用苄星青霉素G可能会延迟青霉素的吸收。