A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.

中文翻译：

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双重机制的抗生素。

通过筛选小分子文库，鉴定出了一种具有靶向叶酸代谢和膜完整性的抗菌活性的双机理化合物，并在体外具有良好的耐药性。