ABSTRACT

In this work, novel injectable and radiopaque calcium phosphate bone cements were prepared using zirconia short fiber as a radiopacifier. The radiopacity, setting time, injectability, anti-washout ability, microstructure, mechanical property, and the in vitro cytocompatibility of the novel cements were evaluated thoroughly. The results reveal that the incorporation of zirconia fiber significantly improves the radiopacity of bone cement while it has no significant effect on the setting time, anti-washout ability, and injectability. The cements are still injectable and show good manual operability. Moreover, the flexural strength and compressive strength of the composite bone cement with 2 wt% fibers are enhanced. Additionally, MTT results reveal that the zirconia fiber doped cements exhibit no cytotoxicity toward osteoblastic MG63 cells, and MG63 cells can adhere and proliferate well on the cements. Therefore, calcium phosphate bone cement containing zirconia fibers has the potential to be used as a bone repair material for minimally invasive surgery.

摘要

在这项工作中，使用氧化锆短纤维作为射线不透明剂制备了新型可注射和不透射线的磷酸钙骨水泥。对新型水泥的射线不透性、凝固时间、可注射性、抗冲刷能力、微观结构、力学性能和体外细胞相容性进行了全面评估。结果表明，氧化锆纤维的掺入显着提高了骨水泥的射线不透性，而对凝固时间、抗冲刷能力和可注射性没有显着影响。水泥仍然是可注射的并且显示出良好的手动操作性。此外，含有2wt%纤维的复合骨水泥的抗弯强度和抗压强度得到提高。此外，MTT 结果表明，氧化锆纤维掺杂的骨水泥对成骨细胞 MG63 没有细胞毒性，MG63细胞可以很好地粘附在骨水泥上并增殖。因此，含有氧化锆纤维的磷酸钙骨水泥具有作为微创手术骨修复材料的潜力。