ABSTRACT

Brain gliomas represent some of the most aggressive tumors encountered by modern medicine and, despite major efforts to optimize early diagnosis and treatment, the prognosis remains poor. Due to the complex structure of the brain and the unique mechanical properties of the extracellular matrix, gliomas invade and expand into the brain parenchyma, along white matter tracts and within perivascular spaces, usually sparing normal vessels. Different methods have been developed to study the mechanical properties of gliomas in a wide range of scales, from cells and the microscale to tissues and the macroscale. In this review, the current view on glioma mechanics is presented and the methods used to determine glioma mechanical properties are outlined. Their principles and current state of affairs are discussed.

摘要

脑胶质瘤是现代医学遇到的一些最具侵袭性的肿瘤，尽管为优化早期诊断和治疗做出了巨大努力，但预后仍然很差。由于大脑的复杂结构和细胞外基质的独特机械特性，胶质瘤沿着白质束和血管周围间隙侵入并扩展到脑实质，通常不影响正常血管。已经开发了不同的方法来研究从细胞和微观尺度到组织和宏观尺度的广泛尺度的神经胶质瘤的机械特性。在这篇综述中，介绍了目前对神经胶质瘤力学的看法，并概述了用于确定神经胶质瘤力学特性的方法。讨论了他们的原则和现状。