ABSTRACT

Objective

Long-term outcomes of eleven cases of facial nerve schwannoma were evaluated and the related literature was reviewed to determine the efficacy of Gamma Knife radiosurgery for treating patients with facial nerve schwannoma.

Methods

Eleven patients with facial nerve schwannoma (7 women and 4 men; mean age, 44.2 years; range, 19–73 years) underwent Gamma Knife radiosurgery. The most common symptoms were facial palsy (n = 10) and hearing loss (n = 7). Five patients presented with headache. Two patients had undergone prior resection. The patients’ clinical and radiographic data were evaluated retrospectively.

Results

For the 11 cases of facial nerve schwannoma, mean tumor volume was 3.1 cm³ (range, 0.4–7.4 cm³) and the mean marginal dose applied was 11.9 Gy (range, 11–13 Gy). The mean follow-up period was 84.3 months (range, 66–117 months). Tumor control was achieved in all patients. At the time of writing, four patients experienced tumor volume regression and the other seven were in stable condition. During follow-up, nine patients experienced no change in their facial function, two experienced deteriorated facial function, and none developed new facial palsy. Ten patients who had serviceable hearing prior to Gamma Knife radiosurgery retained their hearing.

Conclusions

Gamma Knife radiosurgery achieves excellent results with respect to tumor control for 7 years on average. In addition, Gamma Knife radiosurgery provides good results in facial nerve and hearing function at long term. Our series demonstrates that Gamma Knife radiosurgery is an effective and safe treatment for patients with either primary or residual facial nerve schwannoma.

中文翻译：

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伽玛刀放射外科治疗面神经神经鞘瘤的长期结果。

摘要

客观的

评价11例面神经鞘瘤患者的远期疗效，并查阅相关文献，确定伽玛刀放射外科治疗面神经鞘瘤患者的疗效。

方法

11 名面神经神经鞘瘤患者（7 名女性和 4 名男性；平均年龄 44.2 岁；范围 19-73 岁）接受了伽玛刀放射外科手术。最常见的症状是面神经麻痹（n = 10）和听力损失（n = 7）。五名患者出现头痛。两名患者接受了先前的切除术。回顾性评估患者的临床和影像学数据。

结果

对于 11 例面神经神经鞘瘤，平均肿瘤体积为 3.1 cm ³  （范围，0.4-7.4 cm ³），应用的平均边缘剂量为 11.9 Gy（范围，11-13 Gy）。平均随访时间为 84.3 个月（范围为 66-117 个月）。所有患者均达到肿瘤控制。在撰写本文时，4 名患者出现肿瘤体积消退，另外 7 名患者情况稳定。随访期间，9例患者面部功能无变化，2例面部功能恶化，无新发面瘫。10 名在伽玛刀放射外科手术前听力正常的患者保留了他们的听力。

结论

伽玛刀放射外科在肿瘤控制方面取得了平均 7 年的优异成绩。此外，伽玛刀放射外科手术对面部神经和听力功能的长期治疗效果良好。我们的系列展示了伽玛刀放射外科对于原发性或残留面神经神经鞘瘤患者是一种有效且安全的治疗方法。