Introduction: Depressive disorders are the 4th leading cause of health problems and the 2nd leading cause of burden among all diseases. Almost all depressive disorder patients have cognitive impairments to a certain extend. Studies about cognitive impairments in depression had been conducted, but whether cognitive dysfunctions are the cause or the effect is still not clear. Objectives: To analyze the process of working memory and cognitive flexibility impairments in a rat model of depression. Methods: In this experimental study, chronic unpredictable mild stress (CUMS) was used as a model of depression in 30 rats (Rattus novergicus). Cognitive function was assessed with the Morris water maze and attentional set shifting test. Results: This study found a significant difference on day 21 in working memory (p = 0.002) and cognitive flexibility (p = 0.036), which continued to day 41 in working memory (p = 0.001) and cognitive flexibility (p = 0.020). In the CUMS model of depression, parameters peak on day 41 and reveal parameter changes in weight gain (p = 0.018), food intake (p #x3c; 0.001), changes in food intake (p = 0.001), and the sucrose preference (p = 0.005), elevated plus maze (p = 0.001), and light dark box tests (p = 0.020). Conclusion: In a rat model of depression, cognitive impairment preceded depression, but it might be caused by anxiety-like behavior that occurred in early stimulation of chronic unpredictable mild stress.
Neuropsychobiology

中文翻译：

---

认知灵活性和工作记忆受损先于抑郁症：研究抑郁症的大鼠模型。


简介：抑郁症是导致健康问题的第四大原因，也是所有疾病中造成负担的第二大原因。几乎所有抑郁症患者都存在一定程度的认知障碍。已经进行了关于抑郁症认知障碍的研究，但认知功能障碍是原因还是结果仍不清楚。目的：分析抑郁大鼠模型工作记忆和认知灵活性损伤的过程。方法：本实验研究采用慢性不可预测轻度应激（CUMS）作为30只大鼠（ Rattus novergicus ）的抑郁模型。通过莫里斯水迷宫和注意力转移测试评估认知功能。结果：本研究发现第 21 天工作记忆 ( p = 0.002) 和认知灵活性 ( p = 0.036) 存在显着差异，这种差异持续到第 41 天工作记忆 ( p = 0.001) 和认知灵活性 ( p = 0.020)。在抑郁症的 CUMS 模型中，参数在第 41 天达到峰值，并揭示了体重增加 ( p = 0.018)、食物摄入量 ( p #x3c; 0.001)、食物摄入量变化 ( p = 0.001) 和蔗糖偏好 (p = 0.001) 的参数变化。 p = 0.005）、高架十字迷宫（ p = 0.001）和明暗盒测试（ p = 0.020）。结论：在抑郁大鼠模型中，认知障碍先于抑郁发生，但这可能是由慢性不可预测的轻度应激的早期刺激中发生的焦虑样行为引起的。
 神经心理生物学