Background: Anacardium occidentale L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of anti-oxidative endogenous enzymes such as superoxide dismutase, catalase and glutathione, neutrophils infiltration, increase in the activities of myeloperoxidase, malondialdehyde, and pro-inflammatory release. Methods: Paw edema was induced by subplantar injection of carrageenan into the right hind paw in rats, but 30 min before a group of animals were orally treated with 100 mg/kg of cashew nuts to evaluate the anti-inflammatory and anti-oxidative response. Results: In the present work, we found that (1) cashew nuts reduced the development of carrageenan-induced paw edema limiting the formation of edema and pain; (2) cashew nuts ameliorated the diminutions of the anti-oxidative enzymes caused by carrageenan injection; (3) cashew nuts decreased myeloperoxidase malondialdehyde activity induced by carrageenan; and (4) cashew nuts acted by blocking pro-inflammatory cytokines response and nitrate/nitrite formation stimulated by carrageenan injection. Conclusions: The mechanisms of anti-inflammatory and analgesic effects exerted by cashew nuts were relevant to oxygen free radical scavenging, anti-lipid peroxidation, and inhibition of the formation of inflammatory cytokines.

中文翻译：

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腰果（Anacardium occidentale L.）坚果在角叉菜胶诱发的爪水肿的急性实验模型中抵消了氧化应激和炎症。

背景：西洋参L.是具有强大的抗氧化和抗炎特性的药用植物。急性炎症事件导致组织改变，抗氧化内源酶（如超氧化物歧化酶，过氧化氢酶和谷胱甘肽）减少，中性粒细胞浸润，髓过氧化物酶，丙二醛活性增加和促炎性释放。方法：在大鼠右后爪足底注射角叉菜胶可诱发爪状水肿，但在一组动物口服100 mg / kg腰果前30分钟，评估其抗炎和抗氧化反应。结果：在目前的工作中，我们发现（1）腰果减少了角叉菜胶诱发的爪水肿的发展，从而限制了水肿和疼痛的形成；（2）腰果改善了角叉菜胶注射液引起的抗氧化酶的减少；（3）腰果降低了角叉菜胶诱导的髓过氧化物酶丙二醛活性；（4）腰果通过阻断角叉菜胶注射刺激的促炎性细胞因子反应和硝酸盐/亚硝酸盐形成而起作用。结论：腰果发挥抗炎和镇痛作用的机制与清除氧自由基，抗脂质过氧化和抑制炎性细胞因子的形成有关。