Periodontitis is a chronic inflammatory disease. The innate immune mechanism plays a significant role in the aetiopathogenesis of periodontal destruction. The innate immune signalling molecular factors are regulated by small noncoding RNAs called microRNAs (miRNAs). miR‐499 targets many inflammatory cytokine gene mRNAs and has been associated with many inflammatory diseases like rheumatoid arthritis and cardiovascular diseases. Single nucleotide polymorphisms (SNPs) are found to be genetic factors of periodontitis. Not much information is available on miRNA SNP and periodontitis. Thus, the aim of the present study was to find the association of miR‐499 rs3746444 gene polymorphism with chronic periodontitis, aggressive periodontitis and healthy controls.

中文翻译：

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miR-499 rs3746444基因多态性与牙周炎的关联分析

牙周炎是一种慢性炎症性疾病。先天免疫机制在牙周破坏的发病机制中起重要作用。先天免疫信号分子因子受称为 microRNA (miRNA) 的小型非编码 RNA 的调控。miR-499 靶向许多炎性细胞因子基因 mRNA，并与许多炎性疾病如类风湿性关节炎和心血管疾病有关。单核苷酸多态性（SNP）被发现是牙周炎的遗传因素。关于 miRNA SNP 和牙周炎的信息不多。因此，本研究的目的是发现 miR-499 rs3746444 基因多态性与慢性牙周炎、侵袭性牙周炎和健康对照之间的关联。