pH-Triggered Self-Assembly of Cellulose Oligomers with Gelatin into a Double-Network Hydrogel.,Macromolecular Bioscience

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pH-Triggered Self-Assembly of Cellulose Oligomers with Gelatin into a Double-Network Hydrogel.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-07-23 , DOI: 10.1002/mabi.202000187
Yuuki Hata ₁ , Tomoya Kojima ₁ , Tohru Maeda ₁ , Toshiki Sawada _{1,

2} , Takeshi Serizawa ₁

Affiliation

Multicomponent systems for self‐assembled molecular gels provide huge opportunities to generate collective or new functions that are not inherent in individual single‐component gels. However, gelation tends to require careful and complicated procedures, because, among a myriad of kinetically trapped structures related to the degree of mixing of multiple components over a wide range of scales, from molecular level to macroscopic scale, a limited number of structures that exhibit the desired function need to be constructed. This study presents a simple method for the construction of double‐network (DN) hydrogels with improved stiffness composed of crystalline cellulose oligomers and gelatin. The pH‐triggered self‐assembly of cellulose oligomers leads to the formation of robust networks composed of crystalline nanofibers in the presence of dissolved gelatin, followed by cooling to allow for the formation of soft gelatin networks. The resultant DN hydrogels exhibit improved stiffness; the improvement in gel stiffness with double networking is comparable to that of previously reported DN hydrogels produced via a time‐consuming enzymatic reaction.

中文翻译：

pH 触发的纤维素低聚物与明胶的自组装成双网络水凝胶。

自组装分子凝胶的多组分系统为产生集体或新功能提供了巨大的机会，这些功能不是单个单组分凝胶所固有的。然而，凝胶化往往需要仔细和复杂的程序，因为在与多种组分在从分子水平到宏观尺度的广泛范围内的混合程度相关的无数动力学捕获结构中，表现出有限数量的结构需要构建所需的功能。本研究提出了一种简单的方法来构建由结晶纤维素低聚物和明胶组成的具有更高刚度的双网络 (DN) 水凝胶。纤维素低聚物的 pH 触发自组装导致在溶解的明胶存在下形成由结晶纳米纤维组成的坚固网络，然后冷却以形成软明胶网络。所得的 DN 水凝胶表现出更高的刚度；双网络对凝胶刚度的改善与先前报道的通过耗时的酶促反应生产的 DN 水凝胶相当。

更新日期：2020-07-23

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