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Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Phytochemistry ( IF 3.2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.phytochem.2020.112458 Luana San de O Brito 1 , Francisco das Chagas L Pinto 1 , Manoel Odorico M de Filho 2 , Danilo D Rocha 2 , Maria Fernanda M Mendoza 2 , Alejandro Pedro Ayala 3 , Beatriz Pinheiro Bezerra 3 , Maria Iracema B Loiola 4 , Kirley M Canuto 5 , Edilberto R Silveira 1 , Otilia Deusdenia L Pessoa 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.phytochem.2020.112458 Luana San de O Brito 1 , Francisco das Chagas L Pinto 1 , Manoel Odorico M de Filho 2 , Danilo D Rocha 2 , Maria Fernanda M Mendoza 2 , Alejandro Pedro Ayala 3 , Beatriz Pinheiro Bezerra 3 , Maria Iracema B Loiola 4 , Kirley M Canuto 5 , Edilberto R Silveira 1 , Otilia Deusdenia L Pessoa 1
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Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.
中文翻译：
来自 Erythroxylum bezerrae 茎皮的托烷生物碱
从 Erythroxylum bezerrae Plowman 茎皮的乙醇提取物中分离出六种先前未描述的托烷生物碱，称为 erythrobezerrines AF。它们的结构是基于 NMR 和 MS 数据的解释阐明的，并且在某些情况下，通过 X 射线衍射分析证实。评估了分离化合物对癌细胞系 L929、PC-3、HCT-116、SNB-19 和 NCI-H460 的细胞毒性，但只有 erythrobezerrine C 显示出中等活性，对 HCT-116 的 IC50 值为 3.38 和 5.43 μM和 NCI-H460，分别。
更新日期：2020-10-01
中文翻译：
来自 Erythroxylum bezerrae 茎皮的托烷生物碱
从 Erythroxylum bezerrae Plowman 茎皮的乙醇提取物中分离出六种先前未描述的托烷生物碱，称为 erythrobezerrines AF。它们的结构是基于 NMR 和 MS 数据的解释阐明的，并且在某些情况下，通过 X 射线衍射分析证实。评估了分离化合物对癌细胞系 L929、PC-3、HCT-116、SNB-19 和 NCI-H460 的细胞毒性，但只有 erythrobezerrine C 显示出中等活性，对 HCT-116 的 IC50 值为 3.38 和 5.43 μM和 NCI-H460，分别。
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