Cellulose valorisation has been successfully addressed for years. However, the use of hemicellulosic hydrolysates is limited due to the presence of C5-sugars and inhibitors formed during pretreatment. Bacillus coagulans is one of the few bacteria able to utilize both C6- and C5-sugars to produce l-lactic acid, but its susceptibility to the lignocellulosic inhibitors needs further investigation. For such a purpose, the tolerance of different B. coagulans strains to increasing concentrations of inhibitors is studied. The isolated A162 strain reached the highest l-lactic acid productivity in all cases (up to 2.4 g L⁻¹ h⁻¹), even in presence of 5 g L⁻¹ of furans and phenols. Remarkably, most of furans and phenolic aldehydes were removed from defined media and hemicellulosic gardening hydrolysate after fermentation with A162. Considering the high productivities and the biodetoxifying effect attained, A162 could be pointed out as a great candidate for valorisation of mixed sugars from hemicellulosic hydrolysates with high inhibitors concentration, promoting the implementation of lignocellulosic biorefineries.

多年来，纤维素增值已得到成功解决。然而，由于存在 C5-糖和预处理过程中形成的抑制剂，半纤维素水解物的使用受到限制。凝结芽孢杆菌是少数能够利用 C6- 和 C5- 糖产生l-乳酸的细菌之一，但其对木质纤维素抑制剂的敏感性需要进一步研究。为此，研究了不同凝结芽孢杆菌菌株对增加浓度的抑制剂的耐受性。分离的 A162 菌株在所有情况下都达到了最高的l-乳酸生产力（高达 2.4 g L ^-1 h ^-1），即使存在 5 g L ^-1呋喃和苯酚。值得注意的是，大多数呋喃和酚醛在用 A162 发酵后从成分确定的培养基和半纤维素园艺水解产物中去除。考虑到高生产率和所达到的生物解毒效果，A162 可以被指出是一种很好的候选物，可用于从高抑制剂浓度的半纤维素水解产物中提取混合糖，促进木质纤维素生物精炼厂的实施。