Systemic Sclerosis (SSc) is an autoimmune idiopathic connective tissue disease, characterized by aberrant fibro-proliferative and inflammatory responses, causing fibrosis of multiple organs. In recent years the interactions between innate and adaptive immune cells with resident fibroblasts have been uncovered. Cross-talk between immune and stromal cells mediates activation of stromal cells to myofibroblasts; key cells in the pathophysiology of fibrosis. These cells and their cytokines appear to mediate their effects in both a paracrine and autocrine fashion. This review examines the role of innate and adaptive immune cells in SSc, focusing on recent advances that have illuminated our understanding of ongoing bi-directional communication between immune and stromal cells. Finally, we appraise current and future therapies and how these may be useful in a disease that currently has no specific disease modifying treatment.

系统性硬化症 (SSc) 是一种自身免疫性特发性结缔组织疾病，其特征是异常的纤维增殖和炎症反应，导致多器官纤维化。近年来，已经发现了先天性和适应性免疫细胞与常驻成纤维细胞之间的相互作用。免疫细胞和基质细胞之间的串扰介导基质细胞活化成肌成纤维细胞；纤维化病理生理学中的关键细胞。这些细胞及其细胞因子似乎以旁分泌和自分泌方式介导它们的作用。本综述研究了先天性和适应性免疫细胞在 SSc 中的作用，重点关注最近的进展，这些进展阐明了我们对免疫细胞和基质细胞之间正在进行的双向通信的理解。最后，