Pulmonary drug delivery offers several benefits for the management of various conditions over other conventional routes. Inhalation of drugs can also be useful for targeting alveolar macrophages and for maintaining a higher drug concentration in the lung tissues to improve the efficacy of drugs and shorten the duration of treatment, thereby reducing drug toxicities. Thus, such an approach is useful in the treatment of various pulmonary and nonpulmonary diseases. Newer techniques and delivery devices have been used for the formulation of inhalable microparticles. Here. we not only focus on advances in inhalation therapy and in the preparation of microparticles, but also address the clinical development and regulatory aspects of such therapies.

与其他传统途径相比，肺部药物输送为各种疾病的管理提供了多种好处。吸入药物还可用于靶向肺泡巨噬细胞和维持肺组织中较高的药物浓度，以提高药物疗效并缩短治疗持续时间，从而降低药物毒性。因此，这种方法可用于治疗各种肺部和非肺部疾病。更新的技术和递送装置已用于可吸入微粒的配制。这里。我们不仅关注吸入疗法和微粒制备方面的进展，还关注此类疗法的临床开发和监管方面。