Catalytic and enantioselective ring-closing C(sp³)‒H amidation of urea derivatives has been unexplored. In this issue of Chem, Meggers and co-workers address this challenge by using a chiral-at-ruthenium catalyst to obtain cyclic 2-imidazolidinones in a highly enantioselective manner. The latter can be converted to chiral vicinal diamines without appreciable loss of enantiopurity.

中文翻译：

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手性钌催化剂发挥作用：获得对映体富集的2-咪唑烷酮

尿素衍生物的催化和对映选择性的闭环C（sp ³）‒H酰胺化尚未得到探索。在本期《化学》杂志中，Meggers及其同事通过使用手性钌催化剂以高对映选择性的方式获得环状2-咪唑啉酮，解决了这一难题。后者可以转化为手性邻二胺，而不会明显损失对映体纯度。