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A humoral solution: Autologous blood products and tissue repair.
Cellular Immunology ( IF 3.7 ) Pub Date : 2020-07-24 , DOI: 10.1016/j.cellimm.2020.104178
Yuval Yogev 1
Affiliation  

Autologous blood-derived products (ABP) are the focus of growing scientific interest and are investigated and used for multiple medical indications. ABPs hold promise thanks to their availability, ease of preparation, and low risk of adverse allogenic reaction, hypersensitivity, and contamination. Compositional analysis of ABPs reveals a diverse mixture of cellular components, cytokines and growth factors that play roles in healing processes such as tissue proliferation and angiogenesis, modulation of the local environment through chemotaxis and regulation of inflammation and the extracellular matrix, as well as several immunomodulatory actions. Thus, the administration of ABP induces supraphysiological levels of components necessary for orchestrating reparative efforts in currently difficult-to-treat medical conditions. In this article, we review the variety of autologous blood-derived products, their composition, current clinical uses, regulatory climate, and mechanisms of action.



中文翻译:

体液解决方案:自体血液制品和组织修复。

自体血液衍生产品(ABP)是日益增长的科学兴趣的焦点,并且已被研究并用于多种医学适应症。由于ABP的可用性,易于制备以及不良同种异体反应,超敏反应和污染的低风险,ABP有望实现。对ABP的成分分析显示,多种细胞成分,细胞因子和生长因子的混合物在愈合过程中起着重要作用,这些过程包括组织增殖和血管生成,通过趋化性和炎症和细胞外基质的调节来调节局部环境以及几种免疫调节剂动作。因此,在当前难以治疗的医疗条件下,ABP的给药诱导了协调修复工作所需的超生理水平的成分。在这篇文章中,

更新日期:2020-07-24
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