Ion channels are transmembrane proteins whose canonical function is the transport of ions across the plasma membrane to regulate cell membrane potential and play an essential role in neural communication, nerve conduction, and muscle contraction. However, over the last few years, non-canonical functions have been identified for many channels, having active roles in phagocytosis, invasiveness, proliferation, among others. The participation of some channels in cell proliferation has raised the question of whether they may play an active role in mitosis. There are several reports showing the participation of channels during interphase, however, the direct participation of ion channels in mitosis has received less attention. In this article, we summarize the current evidence on the participation of ion channels in mitosis. We also summarize some tools that would allow the study of ion channels and cell cycle regulatory molecules in individual cells during mitosis.

离子通道是跨膜蛋白，其典型功能是跨质膜转运离子以调节细胞膜电位，并在神经通讯、神经传导和肌肉收缩中发挥重要作用。然而，在过去的几年里，许多通道已经确定了非规范功能，在吞噬作用、侵袭性、增殖等方面具有积极作用。一些通道参与细胞增殖提出了它们是否可能在有丝分裂中发挥积极作用的问题。有几份报告显示了间期通道的参与，然而，离子通道在有丝分裂中的直接参与较少受到关注。在本文中，我们总结了离子通道参与有丝分裂的当前证据。