Abstract

In this study, a lipid bilayer membrane model was used, in which the bilayer is tethered to a solid substrate with molecular tethers. The V–I characteristics of the lipid bilayers were found to be non-linear which suggests the presence of pores that are voltage-dependent. At high applied voltages, the conductance reached a limiting value, presumably indicating a limit on the maximum pore size. A decrease in the spacing between tethers (increasing tether density) caused a decrease in the membrane’s conductance at high applied voltage, which is consistent with the maximum pore size being determined by the spacing between the tethers. The inclusion of 10 M% cholesterol within the membrane lipid caused a decrease in the membrane conductance. However, the inclusion of higher levels of cholesterol increased the membrane conductance.

Graphic Abstract

中文翻译：

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胆固醇对栓系脂质膜的电压-电流特性的影响。

摘要

在这项研究中，使用了脂质双层膜模型，其中双层通过分子系链拴在固体基质上。发现脂质双层的 V-I 特性是非线性的，这表明存在依赖电压的孔。在施加高电压时，电导达到极限值，大概表明最大孔径的极限。系绳间距的减小（增加系绳密度）导致膜在高施加电压下的电导降低，这与由系绳间距确定的最大孔径一致。膜脂中包含 10 M% 的胆固醇导致膜电导降低。然而，包含更高水平的胆固醇会增加膜电导。

图形摘要