Macrophages are cells of the myeloid lineage with important roles not only in immune regulation and tissue repair, but also in pathological states such as autoimmune disease and cancer. A plethora of macrophage subtypes exist with distinct phenotypes and functions, not least within the tumor microenvironment (TME) of solid tumors. The abundant macrophages located within the TME are often referred to as tumor-associated macrophages (TAMs). TAMs may be pro-inflammatory with antitumor properties, or may have pro-tumor functions such as angiogenesis. Typically, TAMs are endowed with pro-tumor phenotypes, which has led to strategies to deplete or reprogram TAMs within the TME. Although historically recognized as professional antigen presenting cells (APCs), macrophages are often considered inferior in their abilities to process and present antigens in comparison with dendritic cells (DCs). Notwithstanding, this review gives an overview of the potential accessory role that macrophages might have in antigen processing and presentation to T cells within the TME, with implications for the design of novel immunotherapies.

中文翻译：

---

抗原提呈在肿瘤相关巨噬细胞中的作用

巨噬细胞是髓系谱系的细胞，不仅在免疫调节和组织修复中，而且在诸如自身免疫性疾病和癌症等病理状态中也具有重要作用。存在大量具有不同表型和功能的巨噬细胞亚型，尤其是在实体瘤的肿瘤微环境（TME）中。位于TME内的大量巨噬细胞通常称为肿瘤相关巨噬细胞（TAM）。TAM可能是具有抗肿瘤特性的促炎药，或者可能具有促肿瘤功能，例如血管生成。通常，TAM具有促肿瘤表型，这导致了在TME中耗尽或重新编程TAM的策略。尽管历史上公认专业抗原呈递细胞（APC），与树突细胞（DC）相比，巨噬细胞通常被认为处理和呈递抗原的能力较差。尽管如此，本综述概述了巨噬细胞可能在抗原加工和呈递给TME内的T细胞过程中可能具有的辅助作用，并对新型免疫疗法的设计产生了影响。