The chemical biology of IL-12 production via the non-canonical NFkB pathway,RSC Chemical Biology

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The chemical biology of IL-12 production via the non-canonical NFkB pathway
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-07-22 , DOI: 10.1039/d0cb00022a
Peter D Koch _{1,

2} , Mikael J Pittet ₁ , Ralph Weissleder _{1,

2}

Affiliation

Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, identifying means to pharmacologically induce IL-12 production in the tumor microenvironment has become important. In this review, we highlight therapeutics that promote IL-12 induction in tumor-associated myeloid cells through the non-canonical NFkB pathway. We discuss existing clinical trials and briefly examine the additional pathway targets that warrant further exploration for drug discovery.

中文翻译：

通过非经典 NFkB 途径产生 IL-12 的化学生物学

白介素 12 (IL-12) 已成为癌症治疗中有吸引力的细胞因子，因为它具有直接的抗癌作用，并且在增强检查点抑制剂方面发挥着关键作用。鉴于这些多种作用模式，确定在肿瘤微环境中药理学诱导 IL-12 产生的方法变得非常重要。在这篇综述中，我们重点介绍通过非经典 NFkB 途径促进肿瘤相关骨髓细胞中 IL-12 诱导的治疗方法。我们讨论现有的临床试验，并简要检查需要进一步探索药物发现的其他途径目标。

更新日期：2020-07-22

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