This study was conducted to estimate the prevalence, determinants of hepatitis B, hepatitis C and the survival of tuberculosis patients until drug-induced hepatitis. Prospective cohort study design was implemented. The data were collected from September 2016 – May 2019. Systematic random sampling was used to select the study participants. Baseline data were collected before the patient starts DOTS, the sign of liver toxicity was assessed every week. Tuberculosis treatment outcomes and WHO clinical stage was recorded at the end of 6th months. Descriptive statistics were used to estimate the prevalence of hepatitis B, hepatitis C viral infections and their effect on tuberculosis treatment outcomes. Binary logistic regression was used to identify the determinants of hepatitis B and C infections. The Kaplan Meier survival curve was used to estimate the survival of tuberculosis patient and Cox regression was used to identify the predictors of drug-induced hepatitis. A total of 3537 tuberculosis patients were followed. The prevalence of hepatitis B and C viral infection among tuberculosis patients were 15.1 and 17.3% respectively. Hepatitis B viral infection among tuberculosis patients was associated with alcohol, sex, HIV, chronic illness. Hepatitis C viral infection among tuberculosis patients was associated with alcohol, sex, HIV, chronic illness. The incidence density for liver toxicity among tuberculosis patients was 843/15707 person-months and liver toxicity was determined by HIV, Hepatitis B, Hepatitis C, the severity of tuberculosis and chronic illnesses. Decision-makers should consider incorporating screening for hepatitis B and C viral infection during tuberculosis treatment.

中文翻译：

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乙型肝炎和丙型肝炎合并感染结核病的影响，一项前瞻性队列研究。


本研究旨在估计乙型肝炎、丙型肝炎的患病率、决定因素以及结核病患者在药物诱发肝炎之前的生存率。实施了前瞻性队列研究设计。数据收集于2016年9月至2019年5月。采用系统随机抽样的方式选择研究参与者。在患者开始 DOTS 之前收集基线数据，每周评估肝毒性迹象。第 6 个月末记录结核病治疗结果和 WHO 临床分期。使用描述性统计来估计乙型肝炎、丙型肝炎病毒感染的患病率及其对结核病治疗结果的影响。二元逻辑回归用于确定乙型肝炎和丙型肝炎感染的决定因素。 Kaplan Meier 生存曲线用于估计结核病患者的生存率，Cox 回归用于确定药物性肝炎的预测因子。总共对 3537 名结核病患者进行了随访。结核病患者乙型肝炎和丙型肝炎病毒感染率分别为15.1%和17.3%。结核病患者的乙型肝炎病毒感染与酒精、性、艾滋病毒和慢性病有关。结核病患者的丙型肝炎病毒感染与酒精、性、艾滋病毒和慢性病有关。结核病患者肝毒性的发生密度为843/15707人月，肝毒性由HIV、乙型肝炎、丙型肝炎、结核病严重程度和慢性病决定。决策者应考虑在结核病治疗期间纳入乙型肝炎和丙型肝炎病毒感染筛查。