As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS). A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10-year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25–2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.

中文翻译：

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婚姻状况对成年脊索瘤患者总体生存的影响：一项基于SEER的研究。

作为一种罕见的原发性骨肿瘤，尚无研究报道脊索瘤患者预后与婚姻状况之间的关系。我们将1975年至2016年从监测，流行病学和最终结果（SEER）数据库中识别出的脊索瘤患者分为四类：已婚，离婚/分居，丧偶和单身。使用具有对数秩检验和Cox回归的Kaplan-Meier曲线分析婚姻状况对总体生存（OS）的影响。该研究总共包括1080名患者：已婚700例（64.8％），离婚/分居88例（8.1％），丧偶78例（7.2％），单身214例（19.8％）。在这4个组中，丧偶组的5年OS（45.2％），10年OS（12.5％）和中位OS（56.0个月）最低。包括年龄，性别，主要部位，婚姻状况，疾病分期，肿瘤大小，组织学类型和治疗模式，多因素分析表明，婚姻状况仍然是脊索瘤患者的独立危险因素，丧偶患者的OS最低（危险比[HR] 1.71； 95％置信区间[CI] 1.25–2.33， p <0.001）与已婚患者相比。在对主要部位和疾病阶段进行分层后，观察到相似的结果。婚姻状况是成年脊索瘤患者的独立预后指标，婚姻状况有利于患者生存。与已婚患者相比，丧偶患者的死亡风险更高。与已婚患者相比，置信区间为95％[CI] 1.25–2.33，p <0.001）。在对主要部位和疾病阶段进行分层后，观察到相似的结果。婚姻状况是成年脊索瘤患者的独立预后指标，婚姻状况有利于患者生存。与已婚患者相比，丧偶患者的死亡风险更高。与已婚患者相比，置信区间为95％[CI] 1.25–2.33，p <0.001）。在对主要部位和疾病阶段进行分层后，观察到相似的结果。婚姻状况是成年脊索瘤患者的独立预后指标，婚姻状况有利于患者生存。与已婚患者相比，丧偶患者的死亡风险更高。