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Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
Food & Function ( IF 5.1 ) Pub Date : 2020-07-23 , DOI: 10.1039/d0fo01147a
Javier Diaz-Castro 1 , Pablo Javier Mira-Rufino 2 , Jorge Moreno-Fernandez 1 , Ignacio Chirosa 3 , Javier Luis Chirosa 3 , Rafael Guisado 4 , Julio J Ochoa 1
Affiliation  

Bone and energy metabolism are profoundly influenced by exercise. The objective of this study was to determine for the first time whether a short-term supplementation with ubiquinol could have a modulating effect on bone turnover and energy metabolism associated with strenuous exercise. The participants (n = 100 healthy and well-trained firemen) were randomly divided into two groups: ubiquinol group (ubiquinol (200 mg day−1)) and control group (placebo) for two weeks. The protocol consisted of conducting two identical strenuous exercise tests with a rest period between tests of 24 h. Blood samples were collected before supplementation (basal value) (T1), after supplementation (T2), after the first physical exercise test (T3), after 24 h of rest (T4), and after the second physical exercise test (T5). Parathyroid hormone (PTH), osteocalcin (OC), osteoprotegerin (OPG), osteopontin (OPN), sclerotin (SOST), alkaline phosphatase (AP), adrenocorticotropin (ACTH), insulin, leptin, adrenaline, noradrenaline and peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) were determined. Our protocol increased ACTH, SOST, PTH and OC levels, while it decreased OPN. This protocol also increased adrenaline, noradrenaline and PCG-1α, and decreased insulin. After ubiquinol supplementation, PTH, OC, OPG, alkaline phosphatase, leptin, insulin, noradrenaline and PGC-1α levels increased in the supplemented group compared to the control group after the exercise protocol. Strenuous exercise has a clear effect on energy metabolism and bone turnover. These effects are modulated by ubiquinol supplementation, which especially increases the biomarkers of bone formation during strenuous exercise. In addition, ubiquinol has a beneficial effect on the mobilization of energy sources, fact that it could represent an ergogenic and physiological advantage for skeletal muscles.

中文翻译:

在高强度运动中,补充泛醇可调节能量代谢和骨骼更新。

骨骼和能量代谢受到运动的深刻影响。这项研究的目的是第一次确定短期补充泛醇是否可以对剧烈运动相关的骨转换和能量代谢产生调节作用。参与者(n = 100名健康且训练有素的消防员)被随机分为两组:泛醇组(泛醇(200 mg第-1天)))和对照组(安慰剂)两周。该方案包括进行两次相同的剧烈运动测试,测试之间的休息时间为24小时。补充前(基础值)(T1),补充后(T2),第一次体能测试(T3),静息24小时(T4)和第二次体能测试(T5)后采集血液样本。甲状旁腺激素(PTH),骨钙素(OC),骨保护素(OPG),骨桥蛋白(OPN),硬化蛋白(SOST),碱性磷酸酶(AP),肾上腺皮质激素(ACTH),胰岛素,瘦素,肾上腺素,去甲肾上腺素和过氧化物酶体增殖物激活受体测定了γ共活化剂-1α(PGC-1α)。我们的协议增加了ACTH,SOST,PTH和OC的水平,同时降低了OPN。该方案还增加了肾上腺素,去甲肾上腺素和PCG-1α,并减少了胰岛素。补充泛醇后,运动后与对照组相比,补充组的PTH,OC,OPG,碱性磷酸酶,瘦素,胰岛素,去甲肾上腺素和PGC-1α的水平升高。剧烈运动对能量代谢和骨骼更新有明显影响。这些作用可以通过补充泛醇来调节,特别是在剧烈运动过程中,可以增加骨骼形成的生物标志物。此外,泛醇对能源的调动具有有益作用,这一事实可能代表了骨骼肌的人机化和生理优势。剧烈运动对能量代谢和骨骼更新有明显影响。这些作用可以通过补充泛醇来调节,特别是在剧烈运动过程中,可以增加骨骼形成的生物标志物。此外,泛醇对能源的调动具有有益作用,这一事实可能代表了骨骼肌的人机化和生理优势。剧烈运动对能量代谢和骨骼更新有明显影响。这些作用可以通过补充泛醇来调节,特别是在剧烈运动过程中,可以增加骨骼形成的生物标志物。此外,泛醇对能源的调动具有有益的作用,这一事实可以代表骨骼肌的人机化和生理优势。
更新日期:2020-09-23
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