Elucidation of the Mechanism by Which a ADAMTS5 Gene MicroRNA-Binding Site Single Nucleotide Polymorphism Affects the Risk of Osteoarthritis.,Genetic Testing and Molecular Biomarkers

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Elucidation of the Mechanism by Which a ADAMTS5 Gene MicroRNA-Binding Site Single Nucleotide Polymorphism Affects the Risk of Osteoarthritis.
Genetic Testing and Molecular Biomarkers ( IF 1.1 ) Pub Date : 2020-07-31 , DOI: 10.1089/gtmb.2020.0067
Kedi Weng ₁ , Minjuan Luo ₂ , Dahai Dong ₃

Affiliation

Purpose: The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) within the 3′ untranslated region of the microRNA (miRNA)-binding site of the ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) gene and the risk of knee osteoarthritis (KOA) and its mechanism.

中文翻译：

阐明ADAMTS5基因MicroRNA结合位点单核苷酸多态性影响骨关节炎风险的机制。

目的：本研究的目的是研究具有血小板反应蛋白1型基序5（ ADAMTS5）的ADAM金属肽酶的microRNA（miRNA）结合位点的3'非翻译区域内的单核苷酸多态性（SNP）与该基因之间的关系。膝骨关节炎（KOA）的风险及其机制。

更新日期：2020-08-06

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