To investigate the role of glutathione transferases (GSTs) in the metabolism of inorganic arsenic (iAs), we compared the disposition of iAs and its metabolites in wild-type mice and mice lacking genes encoding GST-P, -M and -T after exposure to 100 ppb iAs in drinking water. We found no differences between the two genotypes in the concentrations of total arsenic or arsenic species in urine, liver, and kidneys. No genotype-dependent differences were found in proportions of arsenicals in the tissues, and only small differences were observed in the urine. Thus, under these conditions, GST-P, -M and -T did not play a significant role in iAs metabolism in mice.

中文翻译：

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缺乏编码 GST-P、GST-M 和 GST-T 基因的小鼠体内无机砷的代谢。

为了研究谷胱甘肽转移酶 (GST) 在无机砷 (iAs) 代谢中的作用，我们比较了暴露后 iAs 及其代谢物在野生型小鼠和缺乏编码 GST-P、-M 和 -T 基因的小鼠中的分布至 100 ppb iAs 在饮用水中。我们发现两种基因型在尿液、肝脏和肾脏中总砷或砷种类的浓度方面没有差异。在组织中砷的比例方面没有发现基因型依赖性差异，在尿液中仅观察到微小的差异。因此，在这些条件下，GST-P、-M 和-T 在小鼠的 iAs 代谢中没有发挥重要作用。