The current study aimed to evaluate the effect of garlic on induced oral Mucositis of Albino rats subjected to different gamma radiation doses. All rats were divided into subgroups and irradiated according to the assigned doses except two control groups. The irradiated rats were subjected to induce mucositis in 1, 2 and 3 days after irradiation. Subgroups were orally administered garlic with doses of 500 mg/kg body weight from the beginning of irradiation process. The right buccal mucosa specimens were excised, processed and stained with Hematoxylin and Eosin. Morphometric and Statistical analyses were carried out for epithelial thickness to detect differences between groups. The irradiated subgroups revealed histopathological aggravated changes with applied doses. The garlic succeeded to reduce the histological changes in the buccal mucosa and also to preserve epithelial thickness. Statistically, the epithelial thicknesses were decreased in an inverse relation with irradiation doses. The current study displayed that the garlic administration could help to a great extent to overcome the Mucositis of buccal mucosa resulting from the exposure to different doses of gamma irradiation.

中文翻译：

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大蒜是否可以改善受到伽马辐射的白化大鼠的诱导性粘膜炎的组织学改变？

目前的研究旨在评估大蒜对接受不同伽马辐射剂量的白化大鼠诱导性口腔粘膜炎的影响。除两个对照组外，将所有大鼠分为亚组并根据指定剂量进行照射。辐照大鼠在辐照后1、2、3天诱发粘膜炎。从辐照过程开始，亚组口服大蒜剂量为 500 mg/kg 体重。右颊粘膜标本被切除、处理并用苏木精和伊红染色。对上皮厚度进行形态测量和统计分析以检测组间差异。辐照亚组揭示了组织病理学随应用剂量的加重变化。大蒜成功地减少了颊粘膜的组织学变化，并保持了上皮厚度。从统计学上讲，上皮厚度与照射剂量呈负相关。目前的研究表明，大蒜给药可以在很大程度上帮助克服因暴露于不同剂量的伽马射线而导致的颊粘膜粘膜炎。