Abstract

Campomanesia xanthocarpa popularly known as gabiroba is used as a medicinal plant for the treatment of inflammatory diseases, ulcers, among other uses, requiring studies to assist in proving these activities. In this study, the extract of leaves from C. xanthocarpa (CxHE) was submitted to assays of formalin-induced paw-licking, peritonitis induced by lipopolysaccharide and carrageenan-induced mechanical hyperalgesia tests. In chemical analysis, a preliminary phytochemical screening and the determination of phenol and flavonoid content were carried out, in addition to analysis by ESI-MS/MS system and HPLC-DAD system. The CxHE presented compounds such as tannins, triterpenoids, steroids and saponins and content of phenols (35.9 ± 1.3 GAE/g extract) and flavonoids (23.3 ± 2.1 mg EQ/g extract). Protocatechuic acid, gallic acid, ethyl gallate, quercetin, and 3-methyl epigallocatechin gallate, alpha and beta-amyrins were identified. CxHE at doses of 10-1000 mg/kg p.o. demonstrated anti-inflammatory and antinociceptive effects in all in vivo assays employed in this study.

Dereplication and evaluation of the antinociceptive and anti-inflammatory activity of hydroethanolic extract of leaves from Campomanesia xanthocarpa O. BergAll authorsFabrício Damasceno Leandro,Layla Dutra Marinho Cabral,Tallita Marques Machado,Hector Henrique Ferreira Koolen,Felipe Moura Araújo da Silva,Fernanda Guilhon-Simplicio ,Marcelo Aparecido da Silva,Alexandre Giusti-Paiva,Clarice de Carvalho Veloso Moura &Geraldo Alves da Silvahttps://doi.org/10.1080/14786419.2020.1795654

Published online:

23 July 2020

中文翻译：

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Campomanesia xanthocarpa O. Berg 叶子的水乙醇提取物的镇痛和抗炎活性的去复制和评价

摘要

Campomanesia xanthocarpa通常被称为 gabiroba，被用作治疗炎症性疾病、溃疡等用途的药用植物，需要研究以帮助证明这些活性。在本研究中，C. xanthocarpa的叶子提取物(CxHE) 接受福尔马林诱导的舔爪、脂多糖诱导的腹膜炎和角叉菜胶诱导的机械痛觉过敏试验。在化学分析方面，除了通过ESI-MS/MS系统和HPLC-DAD系统进行分析外，还进行了初步植物化学筛选和苯酚和黄酮含量的测定。CxHE 展示了单宁、三萜、类固醇和皂苷等化合物以及酚类（35.9 ± 1.3 GAE/g 提取物）和黄酮类化合物（23.3 ± 2.1 mg EQ/g 提取物）的含量。鉴定了原儿茶酸、没食子酸、没食子酸乙酯、槲皮素和 3-甲基表没食子儿茶素没食子酸酯、α 和 β-香树脂素。CxHE剂量10-1000毫克/公斤的口服证明在所有的抗炎和镇痛作用的体内 本研究中使用的检测方法。

消除复制和叶的提取物hydroethanolic的镇痛和抗炎活性的评价Campomanesia xanthocarpa O.伯格所有作者法布里西奥Damasceno莱昂德罗，莱拉·杜特拉马里尼奥卡布拉尔，Tallita马克斯·马查多，赫克托·恩里克·费雷拉Koolen，菲利普·莫拉阿劳霍·达席尔瓦，费尔南达Guilhon -Simplicio 、Marcelo Aparecido da Silva、Alexandre Giusti-Paiva、Clarice de Carvalho Veloso Moura和Geraldo Alves达席尔瓦https://doi.org/10.1080/14786419.2020.1795654

在线发布：

2020 年 7 月 23 日