On the basis of Phoenix dactylifera L. seeds, the effect of acetone, ethanol, and water on total phenolic content (TPC), total flavonoid content (TFC), total anthocyanin content (TAC), and antibacterial activity against Listeria monocytogenes, Staphylococcus aureus, Salmonella enterica, and Escherichia coli was examined. Here, the augmented simplex‐centroid mixture design was implemented. All the independent and response variables were fitted to linear, quadratic, and special cubic models. The best results were obtained for the ternary mixtures, presenting TPC, TFC, TAC, L. monocytogenes, and anti‐S. enterica activities; acetone–ethanol (53.32%–45.31%) with 25.46 mm for anti‐S. aureus and acetone–water (50.19%–48.11%) with 24.56 mm for anti‐E. coli activities were the best solvent mixtures. Optimal mixture predicted for highest phytochemical content corresponds to 22.39%, 37.37%, and 40.24% of acetone, ethanol, and water, respectively. While the optimal extraction mixture predicted for anti‐foodborne pathogens activities contains 39.72% of acetone, 18.87% of ethanol, and 41.41% of water.

中文翻译：

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Phoenix dactylifera L.种子提取的多目标优化：植物化学成分和抗菌活性的混合物设计方法

在Phoenix dactylifera L.种子的基础上，丙酮，乙醇和水对总酚含量（TPC），总黄酮含量（TFC），总花色苷含量（TAC）和对单核细胞增生李斯特菌，金黄色葡萄球菌的抗菌活性的影响，沙门氏菌和大肠杆菌进行了检查。在这里，实现了增强的单纯形-质心混合设计。所有自变量和响应变量都拟合到线性，二次和特殊三次模型。对于三元混合物，呈现TPC，TFC，TAC，单核细胞增生李斯特氏菌和抗小肠链球菌的效果最佳。活动；抗金黄色葡萄球菌的丙酮-乙醇（53.32％–45.31％）（25.46毫米）和抗大肠杆菌活性的丙酮-水（50.19％–48.11％）（24.56毫米）是最佳的溶剂混合物。预测最高植物化学含量的最佳混合物分别对应于丙酮，乙醇和水的22.39％，37.37％和40.24％。预测抗食源性病原体活性的最佳提取混合物含有39.72％的丙酮，18.87％的乙醇和41.41％的水。