The γδ T cells play an important role in both mice and humans as a source of the cytokine IL‐17, which is key for immune resistance to certain pathogens. In mice, most of these IL‐17 producers, termed γδT‐17 cells, actually comprise two distinct types: those expressing an invariant Vγ6Vδ1⁺ TCR and those expressing a Vγ4⁺ TCR. Murine γδT‐17 cells acquire an inherent bias to produce IL‐17 and other “type 17” cytokines during thymic development. The similarities and differences between the two mouse γδT‐17 types are reviewed here, and the potential implications of their differences are discussed. There is some evidence that two distinct TCR‐defined IL‐17‐producing γδ T cell subsets also exist in humans, but unlike the mouse γδT‐17 cells, these cells are probably not imprinted with an IL‐17 bias during thymic development, but rather acquire an IL‐17 bias in the periphery.

中文翻译：

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产生 γδ T 细胞的两个功能不同的 IL-17 亚群。

γδ T 细胞作为细胞因子 IL-17 的来源在小鼠和人类中都发挥着重要作用，IL-17 是对某些病原体产生免疫抗性的关键。在小鼠中，大多数这些 IL-17 产生者，称为 γδT-17 细胞，实际上包含两种不同的类型：表达不变 Vγ6Vδ1 ⁺ TCR 的细胞和表达 Vγ4 ^+的细胞TCR。鼠 γδT-17 细胞在胸腺发育过程中获得产生 IL-17 和其他“17 型”细胞因子的固有偏好。本文回顾了两种小鼠 γδT-17 类型之间的异同，并讨论了它们差异的潜在影响。有证据表明，人类中也存在两种不同的 TCR 定义的产生 IL-17 的 γδT 细胞亚群，但与小鼠 γδT-17 细胞不同，这些细胞在胸腺发育过程中可能没有被 IL-17 偏向印记，但而是在外围获得 IL-17 偏差。