The therapy of cancer remains a major challenge for modern medicine. Complementary to classical treatments, the use of photodynamic therapy (PDT) has received increasing attention over the last decades. Among the classes of PDT photosensitizers (PSs) investigated, Ru^II polypyridine complexes are currently considered as a valuable option. To improve the water solubility of these lipophilic compounds and generate a drug delivery system, these complexes can be encapsulated with polymers. Herein, the physical encapsulation of the photoactive [Ru((E,E')‐4,4'‐bis[p‐methoxystyryl]‐2,2'‐bipyridine)₃][PF₆]₂ complex with the polymer Pluronic F‐127/Poloxamer‐407 is presented. The resulting spherical particles were found to have a toxic effect in the micromolar range in human cervical carcinoma cells upon light irradiation (500 nm).

中文翻译：

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用于光动力疗法的Pluronic F-127 / Poloxamer-407钌（II）聚吡啶复合物的聚合物封装的合成，表征和生物学评估

癌症的治疗仍然是现代医学的主要挑战。在过去的几十年中，作为经典疗法的补充，光动力疗法（PDT）的使用受到越来越多的关注。在研究的PDT光敏剂（PSs）中，Ru ^II聚吡啶复合物目前被认为是有价值的选择。为了改善这些亲脂性化合物的水溶性并产生药物递送系统，可以将这些复合物用聚合物包封。在这里，光活性[Ru（（E，E '）-4,4'-双[对-甲氧基苯乙烯基] -2,2'-联吡啶）₃ ] [PF ₆ ] ₂的物理包封介绍了与聚合物Pluronic F-127 / Poloxamer-407形成的复合物。发现所得的球形颗粒在光照射（500nm）时对人宫颈癌细胞具有微摩尔范围的毒性作用。