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Advances in Total Synthesis of Some 2,3,5-Trisubstituted Tetrahydrofuran Natural Products.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-07-23 , DOI: 10.1002/asia.202000753 Rodney A Fernandes 1 , Ramdas S Pathare 1 , Dnyaneshwar A Gorve 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-07-23 , DOI: 10.1002/asia.202000753 Rodney A Fernandes 1 , Ramdas S Pathare 1 , Dnyaneshwar A Gorve 1
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2,3,5‐Trisubstituted tetrahydrofuran moiety is ubiquitous in natural products. These have served as appealing candidates for total synthesis due to their varied bio‐ and pharmaceutical activities. This tutorial review delineates the ingenious efforts by many researchers in the total synthesis of selected natural products based on a common 2,3,5‐trisubstituted tetrahydrofuran core structure. Many of the syntheses display nuanced interplay between new methods and the ingenuity of planned strategies achieved through catalysis or cascade chemistry. In some cases, the chiron approach has come quite handy, wherein the structural features and the stereochemistry in select molecules could map well with naturally available starting materials. This compilation also aims to enhance the diversity space based on these natural products and further interest in sustainable total synthesis.
中文翻译：
2，3，5-三取代四氢呋喃天然产物的全合成研究进展。
2,3,5-三取代的四氢呋喃部分在天然产物中无处不在。由于它们具有多种生物和药物活性，它们已成为全合成的诱人候选物。本教程概述了许多研究人员在基于常见的2,3,5-三取代四氢呋喃核心结构的选定天然产物的总合成中的巧妙努力。许多合成方法在新方法和通过催化或级联化学实现的计划策略的独创性之间显示出细微的相互作用。在某些情况下，Chiron方法非常方便，其中某些分子的结构特征和立体化学可以与天然起始原料很好地映射。
更新日期：2020-09-14
中文翻译：
2，3，5-三取代四氢呋喃天然产物的全合成研究进展。
2,3,5-三取代的四氢呋喃部分在天然产物中无处不在。由于它们具有多种生物和药物活性，它们已成为全合成的诱人候选物。本教程概述了许多研究人员在基于常见的2,3,5-三取代四氢呋喃核心结构的选定天然产物的总合成中的巧妙努力。许多合成方法在新方法和通过催化或级联化学实现的计划策略的独创性之间显示出细微的相互作用。在某些情况下，Chiron方法非常方便，其中某些分子的结构特征和立体化学可以与天然起始原料很好地映射。
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