Modified Galacto- or Fuco-Clusters Exploiting the Siderophore Pathway to Inhibit the LecA- or LecB-Associated Virulence of Pseudomonas aeruginosa.,ChemBioChem

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Modified Galacto- or Fuco-Clusters Exploiting the Siderophore Pathway to Inhibit the LecA- or LecB-Associated Virulence of Pseudomonas aeruginosa.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-07-23 , DOI: 10.1002/cbic.202000490
Mimouna Madaoui ₁ , Olivier Vidal ₂ , Albert Meyer ₁ , Mathieu Noël ₁ , Jean-Marie Lacroix ₂ , Jean-Jacques Vasseur ₁ , Alberto Marra ₁ , François Morvan ₁

Affiliation

Trojan horse strategy: Glycocluster‐siderophores were synthesised to target LecA and LecB lectins contained in the outer membrane and inside the bacterium of P. aeruginosa. The galactoclusters with catechol moieties were able to hijack the iron transport and exhibit a inhibitory effect. This result shows that LecA localised in the outer membrane of P. aeruginosa is involved in the infection process.

中文翻译：

修饰的半乳糖簇或岩藻簇利用铁载体途径抑制铜绿假单胞菌的LecA或LecB相关毒力。

特洛伊木马策略：合成了糖簇-铁载体，以靶向铜绿假单胞菌细菌外膜和细菌内部的LecA和LecB凝集素。具有邻苯二酚部分的半乳糖簇能够劫持铁运输并表现出抑制作用。该结果表明，位于铜绿假单胞菌外膜中的LecA参与了感染过程。

更新日期：2020-07-23

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