Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease,Annals of the New York Academy of Sciences

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Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-07-22 , DOI: 10.1111/nyas.14436
Mazel Mihardja ₁ , Jaydeep Roy ₁ , Kan Yin Wong ₁ , Luca Aquili ₂ , Boon Chin Heng _{3,

4} , Ying-Shing Chan ₁ , Man Lung Fung ₁ , Lee Wei Lim _{1,

3}

Affiliation

Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterized by the hallmark pathologies of amyloid‐beta plaques and neurofibrillary tangles. Symptoms of this devastating disease include behavioral changes and deterioration of higher cognitive functions. Impairment of neurogenesis has also been shown to occur in AD, which adversely impacts new neuronal cell growth, differentiation, and survival. This impairment possibly results from the cumulative effects of the various pathologies of AD. Preclinical studies have suggested that the administration of melatonin—the pineal hormone primarily responsible for the regulation of the circadian rhythm—targets the effects of AD pathologies and improves cognitive impairment. It is postulated that by mitigating the effect of these pathologies, melatonin can also rescue neurogenesis impairment. This review aims to explore the effect of AD pathologies on neurogenesis, as well as the mechanisms by which melatonin is able to ameliorate AD pathologies to potentially promote neurogenesis.

中文翻译：

阿尔茨海默病神经发生和褪黑激素调节的治疗潜力

阿尔茨海默病 (AD) 是一种与年龄相关的神经退行性疾病，其特征是淀粉样蛋白 β 斑块和神经原纤维缠结的标志性病理。这种破坏性疾病的症状包括行为改变和高级认知功能的恶化。AD 中也显示神经发生受损，这对新神经元细胞的生长、分化和存活产生不利影响。这种损害可能是由各种 AD 病理学的累积效应引起的。临床前研究表明，褪黑激素（主要负责调节昼夜节律的松果体激素）的给药针对 AD 病理的影响并改善认知障碍。据推测，通过减轻这些病理的影响，褪黑激素还可以挽救神经发生障碍。本综述旨在探讨 AD 病理对神经发生的影响，以及褪黑激素能够改善 AD 病理以潜在促进神经发生的机制。

更新日期：2020-07-22

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