Objective

To describe the incidence of postanesthetic signs of colic (PASC) in horses and determine if perianesthetic administration of hydromorphone was associated with an increased risk of PASC.

Study design

Retrospective, cohort study.

Animals

A total of 409 horses.

Methods

Anesthesia and clinical records of horses admitted for various procedures from July 2018 to September 2019 were reviewed. Signs of colic and interventions were recorded up to 48 hours after anesthesia. A binomial logistic regression model was used to evaluate the association between the type of surgery, administration of hydromorphone, the duration of anesthesia and the incidence of PASC.

Results

Overall, 25 (6.1%) horses developed PASC within 48 hours of general anesthesia. Of 60 horses that underwent colic surgery, 16 (26.7%) developed PASC. Of 349 horses that underwent noncolic procedures, nine (2.6%) developed PASC. Thus, the incidence of PASC was higher in horses that underwent colic surgery than in horses that underwent noncolic procedures [odds ratio (OR) = 13.74 (5.73–32.95)]. No effect of hydromorphone on the incidence of PASC was identified [OR = 1.61 (0.71–3.62)]. Longer procedures (>2 hours) were identified as an independent risk factor for PASC [OR = 4.13 (1.52–11.22)].

Conclusions

No association between hydromorphone and an increase in the incidence of PASC was identified. Anesthesia for colic surgery and duration of anesthesia were associated with an increased risk of PASC.

Clinical relevance

Hydromorphone did not increase the incidence of PASC in this population.

中文翻译：

---

回顾性评估麻醉后氢吗啡酮对马绞痛麻醉后症状发生率的影响。

目的

描述马的绞痛麻醉后症状（PASC）的发生率，并确定氢吗啡酮的麻醉后给药是否与PASC风险增加相关。

学习规划

回顾性，队列研究。

动物

共有409匹马。

方法

回顾了2018年7月至2019年9月接受各种手术的马的麻醉和临床记录。麻醉后长达48小时记录了绞痛和干预的迹象。使用二项式logistic回归模型评估手术类型，氢吗啡酮给药，麻醉时间和PASC发生率之间的关联。

结果

总体而言，在全身麻醉的48小时内，有25匹马（6.1％）出现了PASC。在接受结肠手术的60匹马中，有16匹（26.7％）患了PASC。在349匹接受非绞痛手术的马中，有9匹（2.6％）患了PASC。因此，进行绞痛手术的马匹中PASC的发生率高于进行非绞痛手术的马匹[比值比（OR）= 13.74（5.73–32.95）]。没有发现氢吗啡酮对PASC发生率有影响[OR = 1.61（0.71-3.62）]。较长的手术时间（> 2小时）被确定为PASC的独立危险因素[OR = 4.13（1.52-11.22）]。

结论

氢吗啡酮与PASC发生率增加之间没有关联。结肠手术麻醉和麻醉持续时间与PASC风险增加有关。

临床相关性

氢吗啡酮不会增加该人群中PASC的发生率。