Purpose

To analyse the factors affecting laminar resorption in the UK osteo-odonto-keratoprosthesis (OOKP) cohort and present a detailed review.

Methods

A retrospective review of the case records of the patients who underwent OOKP between 1996 and 2014 was performed at the Sussex Eye Hospital in Brighton, UK.

Results

Sixty-four patients (25 females and 39 males) were included, and 74 laminae were implanted consisting of 3 tibial grafts, 11 tooth allografts and 60 tooth autografts. In total, 69% (n = 51) showed resorption. Non-smokers had better oral health compared to smokers (71% vs 50%, respectively). Poor oral health was strongly associated with poor quality dentition and edentulism (p < 0.001). The laminar thickness and waiting for the time between stages 1 and 2 surgeries did not show significant influence on the onset and progression of resorption. From the Cox multivariate analysis for autografts, smoking, age and gender were not associated with a statistically significant difference in the rates of resorption. The maximum number of laminae with resorption belonged to Stevens-Johnson syndrome patients (n = 32 or 43%).

Conclusions

Two-thirds of the cases of resorption were detected in the first three years of OOKP, and the maximum were noted in the first year of follow up (40%). The laminar thickness did not influence the post-operative onset and progression of resorption. The presence of resorption after stage 1 did not show a measurable effect on the onset and progression of post-stage 2 resorption.

中文翻译：

---

层流吸收的临床研究：第1部分-影响层流吸收的因素。

目的

为了分析影响英国骨-齿-角膜假体（OOKP）队列中层流吸收的因素，并进行了详细的综述。

方法

在英国布莱顿的苏塞克斯眼科医院对1996年至2014年接受OOKP治疗的患者的病例记录进行了回顾性审查。

结果

包括64例患者（25例女性和39例男性），并植入74片椎板，其中包括3枚胫骨移植物，11枚异体牙和60枚自体牙。总共有69％（n = 51）显示出吸收。与吸烟者相比，非吸烟者的口腔健康更好（分别为71％和50％）。不良的口腔健康与劣质的牙列和无齿症密切相关（p <0.001）。层流厚度和第1阶段和第2阶段手术之间的等待时间对吸收的开始和进展没有显着影响。根据自体移植物的Cox多变量分析，吸烟，年龄和性别与吸收率在统计学上无显着差异。具有吸收功能的最大薄片层属于史蒂文斯-约翰逊综合征患者（n = 32或43％）。

结论

在OOKP的前三年中发现了三分之二的吸收病例，而在随访的第一年中发现了最大的病例（40％）。层厚不影响术后开始和吸收的进展。第1阶段后吸收的存在对第2阶段后吸收的开始和进展没有可测量的影响。