Research question

Can the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus induce testis damage and dysfunction?

Design

This is the description of the case of a young man presenting with heavy testicular pain as the first symptom of COVID-19 infection. A review of the literature is also presented.

Results

SARS-CoV-2 may enter into the host cell by binding to angiotensin-converting enzyme 2. This receptor seems to be widely expressed in different testicular cell types, making possible the occurrence of orchitis in male patients with COVID-19 infection. From a review of the literature, it seems that there is currently no evidence of sexual transmission of SARS-CoV-2; however, the possibility of virus-induced testis damage and dysfunction cannot be excluded.

Conclusions

Further studies are necessary on the pathological effect of SARS-CoV-2 in the male reproductive system and to ensure a proper andrological follow-up for male patients.

中文翻译：

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睾丸疼痛是 COVID-19 的一种不寻常表现：SARS-CoV-2 和睾丸的简要回顾。

 研究问题

严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 病毒会引起睾丸损伤和功能障碍吗？

 设计

这是对一名年轻人的病例的描述，该男子以严重睾丸疼痛为 COVID-19 感染的首发症状。还提供了文献综述。

 结果

SARS-CoV-2可能通过与血管紧张素转换酶2结合进入宿主细胞。该受体似乎在不同类型的睾丸细胞中广泛表达，使得感染COVID-19的男性患者出现睾丸炎成为可能。从文献综述来看，目前似乎没有证据表明SARS-CoV-2存在性传播；然而，不能排除病毒引起的睾丸损伤和功能障碍的可能性。

 结论

需要进一步研究 SARS-CoV-2 对男性生殖系统的病理影响，并确保对男性患者进行适当的男科随访。