Cell Chemical Biology ( IF 6.6 ) Pub Date : 2020-07-23 , DOI: 10.1016/j.chembiol.2020.07.004 Stephen M Canham 1 , Yuan Wang 1 , Allen Cornett 1 , Douglas S Auld 1 , Daniel K Baeschlin 2 , Maude Patoor 2 , Philip R Skaanderup 2 , Ayako Honda 1 , Luis Llamas 1 , Greg Wendel 1 , Felipa A Mapa 1 , Peter Aspesi 1 , Nancy Labbé-Giguère 1 , Gabriel G Gamber 1 , Daniel S Palacios 1 , Ansgar Schuffenhauer 2 , Zhan Deng 1 , Florian Nigsch 2 , Mathias Frederiksen 2 , Simon M Bushell 1 , Deborah Rothman 1 , Rishi K Jain 1 , Horst Hemmerle 1 , Karin Briner 1 , Jeffery A Porter 1 , John A Tallarico 1 , Jeremy L Jenkins 1
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Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous value to biomedical research but require substantial effort to ensure diversity as well as quality of the contents. We have assembled a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our approach, lessons learned, and disclosing our current collection of 4,185 compounds with their primary annotated gene targets (https://github.com/Novartis/MoaBox). This physical collection is regularly updated and used broadly both within Novartis and in collaboration with external partners.
中文翻译：
系统化学遗传学图书馆大会。
化学基因库（定义明确的化学探针的集合）为生物医学研究提供了巨大的价值，但需要大量的努力来确保内容的多样性和质量。我们通过数据挖掘和众包机构专业知识组装了一个化学基因库。我们将分享我们的方法，经验教训，并公开我们当前收集的4,185种化合物及其主要的带注释基因靶标（https://github.com/Novartis/MoaBox）。该物理馆藏会定期更新，并在诺华内部以及与外部合作伙伴的广泛使用。
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