Ultra-thin patchy polymer-coated graphene oxide as a novel anticancer drug carrier,Polymer Chemistry

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Ultra-thin patchy polymer-coated graphene oxide as a novel anticancer drug carrier
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-07-22 , DOI: 10.1039/d0py00769b
Vien T. Huynh _{1,

2,

3,

4,

5} , Duc Nguyen _{1,

2,

3,

4,

5} , Liwen Zhu _{1,

2,

3,

4,

5} , Nguyen T. H. Pham _{1,

2,

3,

4,

5} , Pramith Priyananda _{1,

2,

3,

4} , Brian S. Hawkett _{1,

2,

3,

4,

5}

Affiliation

An ultra-thin, graphene oxide (GO) based, anticancer drug carrier was developed using Reversible Addition Fragmentation chain Transfer (RAFT) mediated emulsion polymerisation. Short chain macro-RAFT copolymer, BuPATTC-(BA₄-stat-AA₉-stat-StS₅), was used to disperse the GO in water. Subsequent free radical emulsion polymerisation produced an aqueous suspension of partially polymer-coated GO (PPC-GO). The polymer coating was unevenly distributed, forming a patchy and extremely rough surface on the GO substrate. The use of macro-RAFT copolymers greatly improved the overall colloidal stability of the GO. Furthermore, particle morphologies were found to be controllable by adjusting the amount of monomer starve fed into the polymerisation. PPC-GO was demonstrated to be an effective carrier for the anti-cancer drug doxorubicin (Dox), storing equivalent to its own original weight in Dox. A releasing mechanism using L-ascorbic acid (L-AA) as an agent was reported. Dox release can be triggered by chemical reduction using L-AA, which weakens the hydrogen bonds between Dox and GO. After release of the Dox, the remaining PPC- reduced GO (PPC-rGO) was found to be stable in aqueous suspension.

中文翻译：

超薄斑状聚合物涂层氧化石墨烯作为新型抗癌药物载体

使用可逆加成断裂链转移（RAFT）介导的乳液聚合技术开发了基于超薄氧化石墨烯（GO）的抗癌药物载体。短链大分子RAFT共聚物，BuPATTC-（BA ₄ - stat -AA ₉ - stat -StS ₅），用于将GO分散在水中。随后的自由基乳液聚合产生了部分涂覆有聚合物的GO（PPC-GO）的水性悬浮液。聚合物涂层分布不均匀，在GO基材上形成了斑驳且极为粗糙的表面。大分子RAFT共聚物的使用大大改善了GO的整体胶体稳定性。此外，发现通过调节进料到聚合反应中的单体饥饿量可以控制颗粒形态。PPC-GO被证明是抗癌药物阿霉素（Dox）的有效载体，在Dox中的储藏量与其自身原始重量相当。报道了使用L-抗坏血酸（L - AA ）作为试剂的释放机理。通过化学还原可以触发Dox释放L -AA，削弱Dox和GO之间的氢键。释放Dox后，发现剩余的PPC还原的GO（PPC-rGO）在水性悬浮液中稳定。

更新日期：2020-07-22

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